Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Clayton, A. H., Goldstein, I., Kim, N.
| Tip | Explanation | Example |
|---|---|---|
| Check Ingredients | Choose products with well-known, safe ingredients | Maca, Ginseng |
| Read Customer Reviews | Verify efficacy and safety testimonials | Amazon reviews, forums |
| Consult Healthcare Providers | Especially if on medication or have health issues | Doctor’s advice before use |
| Avoid Unverified Claims | Beware of exaggerated promises or miracle cures | Look for scientific backing |
| Consider Budget | Balance quality and affordability | Compare prices, avoid overly cheap options |
N., Althof, S. E., Faubion, S. S., Faught, B.
M., Parish, S. J., Simon, J. The International Society for the Study of Women's Sexual Health Process of Care for Management of Hypoactive Sexual Desire Disorder in Women. Mayo Clinic Proceedings, 93(4), 467–487.
| Culture/Region | Attitudes Towards Libido Pills | Common Uses | Concerns |
|---|---|---|---|
| Western Countries | Increasing acceptance, often seen as wellness supplements | Enhancing intimacy, confidence | Safety, efficacy, addiction fears |
| Asia | Traditional herbal remedies favored | Natural health, balancing energy | Efficacy skepticism |
| Middle East | Conservative, low openness to libido enhancement products | Limited access, cultural taboos | Social stigma |
| Latin America | Growing acceptance, blend of herbal and modern options | Sexual health empowerment | Regulation, safety concerns |
Female sexual dysfunction (FSD): Prevalence and impact on quality of life (QoL). Mayo Foundation for Medical Education and Research (MFMER). Icahn School of Medicine at Mount Sinai.
This is in contrast to Wisp and Unbound clearly stating that their products use a pea-sized treatment. Leading Edge Health offers a bulk purchase discount, so the more tubes you buy, the more you save. If you buy a 3-month or 6-month supply, you’ll also receive a free box of HerSolution pills. Here’s how the costs work out: Demonstrated efficacy improving arousal issues in multiple clinical studies Convenient $29 online consultation for a prescription Free monthly delivery if prescription filled through partner pharmacy Financial aid available for those who qualify A long list of side effects, some of which can be serious Not for those who have gone through menopause Can be expensive if you don’t have insurance Takes about a month or so to work Addyi (flibanserin) — also known as “the little pink pill” — is an FDA-approved prescription pill to treat Hypoactive Sexual Desire Disorder (HSDD).62 HSDD affects premenopausal women, and it’s believed to be caused by a neurotransmitter imbalance in the brain. However, researchers acknowledge that other reasons, like self-image or happiness in a relationship, can also play a role.18 Additionally, a major part of these symptoms is that they need to be causing you some form of distress.
If you don’t care about not having sexual thoughts or desires, then it isn’t HSDD. To receive a prescription, you’ll need to consult with a physician. If you’d rather not wait to see a doctor in person, you can visit the Addyi website and consult with a doctor online using the telehealth service beyondMD for $29. You’ll fill out a questionnaire about your current health status and lifestyle, and a licensed provider will review it and decide if Addyi sounds like a fit for you. Otherwise, if you prefer to order the prescription through a face-to-face appointment, you can contact Addyi for a list of prescribers. 197 A Double-blind, Placebo-controlled, 2-Way Crossover Study Using Thermography to Assess the Pharmacodynamics of Sildenafil Cream, 3.6% in Healthy Women. The Journal of Sexual Medicine, 17(1), S69. Systematic Review of l-Arginine for the Treatment of Hypoactive Sexual Desire Disorder and Related Conditions in Women. Pharmacy: Journal of Pharmacy Education and Practice, 9(2).
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Kamagra | 100mg | 84 + 6 Pills | 264.44€ 251.85€ | |
| Viagra Generic | 150mg | 90 + 6 Pills | 147.18€ 140.17€ | |
| Viagra Generic | 200mg | 270 + 10 Pills | 379.76€ 361.68€ | |
| Tadalista Super Active | 20mg | 20 + 4 Pills | 92.35€ 87.95€ | |
| Levitra Generic | 60mg | 120 + 8 Pills | 372.33€ 354.60€ | |
| Viagra Super Active | 100mg | 270 + 30 Pills | 390.61€ 372.01€ | |
| Kamagra Soft Tabs | 100 mg | 180 + 8 Pills | 425.45€ 405.19€ | |
| Tadalista Super Active | 20mg | 180 + 20 Pills | 521.59€ 496.75€ | |
| Kamagra Gold | 100 mg | 12 Pills | 55.64€ 52.99€ | |
| Cialis Generic | 10mg | 90 + 6 Pills | 146.17€ 139.21€ | |
| Levitra Generic | 10mg | 20 Pills | 46.54€ 44.32€ | |
| Cialis Generic | 2.5mg | 180 + 10 Pills | 154.86€ 147.49€ | |
| Kamagra Oral Jelly | 100 mg | 110 + 9 Sachets | 334.87€ 318.92€ | |
| Viagra Oral Jelly | 100mg | 90 + 8 Sachets | 258.02€ 245.73€ |
Vyleesi Prices, Coupons and Patient Assistance Programs. Endothelial Nitric Oxide Synthase Regulation in Female Genital Tract Structures.
The active ingredient in Vyleesi is bremelanotide, an FDA-approved drug to treat HSDD. It’s important to note that this medication does bring about the possibility of side effects, including (but not limited to):7 Because Vyleesi can alter your heart rate and blood pressure, it isn’t recommended for people with hypertension or cardiovascular issues. Even if you don’t have those concerns, it’s important to speak with your primary care provider to ensure Vyleesi is safe for you. You can obtain a Vyleesi prescription either through your doctor or the manufacturer’s third-party telehealth partner, Prescribery, for a $29 consultation fee (just click the “Get Vyleesi Online” button on the top of the Vyleesi website). No matter where you receive your prescription from, it will be shipped to you for free from BlinkRx, a specialty pharmacy.
If you have insurance, the cost of Vyleesi may be covered. It’s a good idea vigora spray to check with your plan beforehand to verify. If you don’t have insurance, Vyleesi offers financial assistance through an application on the prescription information website. You need to be at least 18 years old and not insured by a government agency (such as Medicaid) to be eligible for financial aid. Innerbody uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. The Journal of Sexual Medicine, 6, 247-253.
If the doctor you see prescribes the medication, you can pick it up at a local pharmacy or have it shipped to your home for free through Addyi’s partner pharmacy, PhilRx. The cost of the medication varies depending on insurance coverage. Some insurance plans offer Addyi for only $20 each month. If you don’t have insurance, the average cost is around $350 for a 30-day supply. In the past, there was a manufacturer savings program that guaranteed qualifying patients would pay “never more than $149” per month, but that appears to have been discontinued.
The active ingredient in Addyi is the drug flibanserin, which is FDA-approved to treat HSDD. You take Addyi once daily at bedtime. This prescription shouldn’t be taken with alcohol (the other FDA-approved prescription mentioned in this guide, Vyleesi, doesn’t have this restriction). Those who have any liver problems should also avoid the medication. You may experience some side effects on Addyi, including: The prescription’s website includes a comprehensive overview of drug interactions, side effects, and potential risks. Yes, you can have better sex in midlife and in the years beyond.
We recommend bringing up any conditions or medications that might be relevant to your use of Addyi during your doctor consultation. Overall, research points to Addyi being well-tolerated and effective at improving sexual desire in premenopausal individuals with HSDD.55 This medication does take some time to potentially work, however. Like the supplement options, Addyi can take around four weeks to a couple of months before the effects kick in. But, according to the manufacturer, if you haven’t seen any improvement after taking Addyi for eight weeks, then the medication should be discontinued. Clinical trials show a positive impact on HSDD Convenient telehealth consultation and free prescription shipping Financial assistance available for qualifying individuals without insurance There is no restriction on drinking alcohol while using Vyleesi You can get a prescription online through manufacturer’s telemed partner, Prescribery Medication is shipped to you for free from BlinkRx specialty pharmacy Each prescription fill only contains four doses A long list of possible side effects Not for those who have already gone through menopause Not recommended for those with high blood pressure or cardiovascular concerns Can be extremely expensive if you are uninsured and don’t qualify for assistance Vyleesi (bremelanotide) is an FDA-approved injectable prescription medication that can be used as needed to treat Hypoactive Sexual Desire Disorder (HSDD) in premenopausal women.
HSDD is defined as a “persistent or recurrent absence of sexual fantasies and desire for sexual activity” that leads to distress or relationship difficulties. It’s not caused by a medical or mental health issue, relationship problem, or drug use. Essentially, you know you have HSDD if your libido used to be acceptable to you, but it’s recently taken a dip, and this lower libido is causing you distress.18 54 Clinical trials investigating the effectiveness of Vyleesi for the treatment of HSDD have shown promising results. Versus a placebo, researchers reported that Vyleesi “significantly increased sexual desire.”56 To take Vyleesi, you use the autoinjector pen to give yourself an injection under the skin on your thighs or stomach about 45 minutes before sexual activity. The manufacturer notes that it shouldn’t be used more than once per day or more than eight times per month. Testosterone therapy in women: Does it boost sex drive? Treatment of Hypoactive Sexual Desire Disorder Among Women: General Considerations and Pharmacological Options. Focus: Journal of Life Long Learning in Psychiatry, 19(1), 39-45. Integrative Medicine (Fourth Edition), 592-599.e2. Oral L-citrulline supplementation improves erection hardness in men with mild erectile dysfunction.
| Side Effect | Associated Ingredients | Severity | Recommendations |
|---|---|---|---|
| Headaches | Yohimbine, Ginseng | Mild | Reduce dose, stay hydrated |
| Insomnia | Ginseng, Stimulant-based pills | Moderate | Take earlier in the day |
| Increased Heart Rate | Yohimbine, L-Arginine | Moderate | Monitor heart health, consult doctor |
| Gastrointestinal Upset | Tribulus, Ginseng | Mild | Take with food |
| Allergic Reactions | Various herbal components | Variable | Discontinue use, seek medical advice |
Effects of nine weeks L-Carnitine supplementation on exercise performance, anaerobic power, and exercise-induced oxidative stress in resistance-trained males. Journal of Exercise Nutrition & Biochemistry, 22(4), 7-19. Topics in Current Chemistry, 328, 155–240. Seminal plasma magnesium and premature ejaculation: a case-control study. The Role of Magnesium in Hypertension and Cardiovascular Disease. The Journal of Clinical Hypertension, 13(11), 843-847. Effect of Zinc on Testosterone Levels and Sexual Function of Postmenopausal Women: A Randomized Controlled Trial. Journal of Sex & Marital Therapy, 47(8), 804–813. BIOCHEMISTRY OF MOBILE ZINC AND NITRIC OXIDE REVEALED BY FLUORESCENT SENSORS. Adverse Events Associated with Melatonin for the Treatment of Primary or Secondary Sleep Disorders: A Systematic Review. Evaluation of Dietary Niacin and New-Onset Hypertension Among Chinese Adults. Hop extracts and hop substances in treatment of menopausal complaints. Hops for Menopausal Vasomotor Symptoms: Mechanisms of Action. Journal of Traditional and Complementary Medicine, 2(4), 331-339. Efficacy of Tribulus terrestris for the treatment of hypoactive sexual desire disorder in postmenopausal women: a randomized, double-blinded, placebo-controlled trial. Menopause (New York, N.Y.), 23(11), 1252–1256.
A systematic review of clinical trials on Ginkgo (Ginkgo biloba) effectiveness on sexual function and its safety. Journal of ethnopharmacology, 145(3), 715–721. Capsaicinoids Modulating Cardiometabolic Syndrome Risk Factors: Current Perspectives. The effect of melatonin on the sexual function among postmenopausal women: A randomized placebo-controlled trial. Nursing and Midwifery Studies, 6(4), 149. Understanding Unapproved Use of Approved Drugs "Off Label".