There’s very little research on oxytocin as a treatment for sexual dysfunction.
One small study from 2015 found that long-term (eight weeks) intranasal oxytocin (32UI) self-administered by women 50 minutes before sexual intercourse improved both sexual function and symptoms of depression.68 And a 2023 study in men receiving testosterone treatment for erectile dysfunction found that
According to experts, HSDD appears to be caused by an imbalance of certain neurotransmitters and hormones in the brain, which the ingredients in Libido Lift Rx won’t affect.18 Pivoting to the supplement, Hello Cake Drive For Her (previously called “Sex Drive For Her”) is a blend of various herbal ingredients and L-arginine intended to increase sexual desire. While there is some supportive research behind most of this supplement’s ingredients, the evidence isn’t quite as cialis order mastercard strong as it is for VitaFLUX’s nitric-oxide-boosting amino acids. But, if you can’t take a supplement with such a heavy focus on increasing nitric oxide — or if you simply prefer the idea of an herbal supplement and its potential benefits — then Drive For Her is an option worth considering. (As a side note, Drive For Her only requires you to take two capsules daily instead of VitaFLUX’s six.) In addition to Libido Lift Rx and the Drive For Her supplement, it’s worth mentioning that Cake also offers a topical arousal product similar to Wisp’s OMG Cream called “O-Cream Rx for Her.” Both creams include the same 1% concentration of sildenafil (the generic form of Viagra). However, Cake’s prescription is more expensive than Wisp’s for fewer applications.
But, unlike Wisp, Cake does offer an extra strength option containing 3% sildenafil, though that’s even pricier. At this time, we’d only recommend opting for Cake’s O-Cream Rx for Her if you’ve tried a 1% sildenafil topical, found it wasn’t strong enough for your needs, and would like to try the 3% sildenafil extra strength variety. That said, let’s examine the ingredients in Libido Lift Rx and Drive For Her. Libido Lift Rx has a fairly small list of ingredients, containing only L-citrulline, oxytocin, and tadalafil. Let’s cover how this prescription’s inclusions work. oxytocin troches (50-100UI) may be a helpful adjunctive treatment, with 56% of patients (14 out of 26) considered responders to the intervention.69
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Cialis Generic | 2.5mg | 120 + 6 Pills | 128.93€ 122.79€ | |
| Cialis Original | 20mg | 64 + 4 Pills | 274.18€ 261.12€ | |
| Cialis Generic | 5mg | 360 + 10 Pills | 268.08€ 255.31€ | |
| Cialis Generic | 2.5mg | 360 + 10 Pills | 260.03€ 247.65€ | |
| Cialis Generic | 20mg | 60 + 6 Pills | 117.76€ 112.15€ | |
| Cialis Black | 80mg | 20 Pills | 71.83€ 68.41€ | |
| Cialis Generic | 20mg | 270 + 10 Pills | 335.21€ 319.25€ | |
| Cialis Soft Tabs | 20mg | 10 Pills | 39.03€ 37.17€ | |
| Cialis Original | 20mg | 34 + 2 Pills | 183.99€ 175.23€ | |
| Cialis Super Active | 20mg | 20 + 4 Pills | 92.35€ 87.95€ | |
| Cialis Generic | 10mg | 360 + 10 Pills | 388.49€ 369.99€ |
In contrast to the short ingredient list of Libido Lift Rx, Drive For Her contains seven herbal ingredients and one amino acid.
| Side Effect | Frequency | Severity | Recommended Action |
|---|---|---|---|
| Headache | Common | Mild | Over-the-counter pain relief |
| Flushing | Common | Mild | Cool compress, hydration |
| Nausea | Less common | Mild | Take with food |
| Dizziness | Less common | Moderate | Rest and hydration |
| Muscle aches | Rare | Mild | Rest, consult doctor if persists |
Here’s how their potential benefits for female sexual health break down.
(Wisp doesn’t accept insurance at this time, but that’s not all that unusual in the telehealth space.) Additionally, shipping is discreet and always free. However, due to the nature of Wisp’s products, the company does not accept returns or offer refunds. Only if you receive a product in error and contact Wisp within 15 days of receipt will the company investigate the situation and issue a replacement product if deemed appropriate. To learn more about Wisp and the platform’s telehealth visit process, check out our full Wisp review. Best prescription pill and runner-up OTC pill Oral tadalafil (generic Cialis) for women is a fairly specialized offering Libido Lift Rx should work in around 30 minutes and last 24-36 hours Prescription “pills” are actually mint-flavored tablets that dissolve under the tongue Drive For Her supplement ingredients have some supportive research Drive For Her subscriptions take 15% off 10% off prescription treatments using code INNERBODY10 Both are unsafe for those who are pregnant or breastfeeding Supplement may contain traces of all nine major allergens Supplements likely require extended use, contrary to product page information More research needed on both tadalafil and oxytocin for FSD “For Her” meds can’t ship to Alabama, California, South Carolina, Guam, or Puerto Rico Hello Cake (often stylized as just “Cake”) is a telehealth company focused on sexual health.
While the brand offers a wide range of products intended to improve your sexual well-being, we chose its Cake Meds Libido Lift Rx and Hello Cake Drive For Her as our picks for the best prescription pill and runner-up OTC pill. Libido Lift Rx is unique in that it’s the first fast-acting libido-support prescription pill for women that we’ve come across, as of this writing. Most other options on the market are supplements or either prescription or non-prescription topicals. So, as mentioned previously, this dissolvable tablet may be the closest thing to an “instant” female arousal pill, since it should start working in around 30 minutes. If you’re suffering from a form of female sexual dysfunction, like hypoactive sexual desire disorder (HSDD), Libido Lift Rx will not get to the root of the problem. A 2015 study evaluated how Libifem affected sex hormones and sexual function in 80 healthy, menstruating women with self-reported low libido.
Cream is compounded according to your needs based on the information you provide to your Wisp doctor. Cream prescription could be similar or very different from the ones our tester received, as pictured above. (However, based on customer feedback and our tester’s own prescription, the sildenafil is seemingly prescribed in at least a 1% concentration.) As with many other female arousal products, Wisp’s topical is intended to promote better blood flow to improve vaginal lubrication and increase physical arousal.19 43 Here’s how the OMG! Cream ingredients may be able to help: The research on topical sildenafil, the active ingredient in Viagra, as a topical treatment for arousal concerns in women is only in its infancy, but the results are promising. A small 2020 double-blind, placebo-controlled study found that sildenafil cream led to “clinically significant increases in genital and self-reported measures of arousal compared to placebo cream” in six female patients.
It’s worth mentioning that this study specifically used 3.6% sildenafil cream; smaller doses may not have as significant of an effect.9 Ergoloid mesylates, also known as “co-dergocrine mesylate,” is a medication with vasodilatory properties that’s normally used to treat cognitive impairment due to aging, but some older research has investigated it as part of a topical for the treatment of erectile dysfunction (ED).46 60 In a study from 2001, a cream containing testosterone and two “vasoactive agents” (one of which was co-dergocrine mesylate) performed better than plain testosterone cream in treating ED in older men with “low sexual interest.”47 Ultimately, while the existing data behind these ingredients appears promising, more research is needed to fully understand their potential roles in treatments for female sexual dysfunction (FSD). The chart below breaks down the cost of Wisp’s OMG! Cream as both a one-time purchase and a subscription (charged and shipped every three months). Similar to competitors like Promescent, opting for recurring deliveries from Wisp will reduce your cost per bottle. Competitor Hello Cake offers a similar topical, O-Cream Rx For Her, that’s available in either regular (1% sildenafil) or extra strength (3% sildenafil). Participants in the treatment group (600mg per day for eight weeks) experienced a “significant increase” in free testosterone and estradiol,
as well as sexual arousal and desire versus the placebo group.73 Other, unrelated research on fenugreek extract found similar results.
For example, a 12-dose order of regular strength O-Cream Rx is $108 — that’s nearly $70 more than a one-time purchase of a 15-dose bottle of OMG! And since the products from both companies contain at least 1% sildenafil, there doesn’t appear to be a dose-dependent reason for this significant price difference. Cream contains 15 treatments only if you adhere to Wisp’s instructions to use a pea-sized amount. Using any more or less than the suggested quantity can alter the number of uses you get out of a bottle — and how often you need to reorder. While Wisp’s subscriptions do net you a nice 10-15% discount, we wish the shipping intervals could cialis woman be modified.
Everyone’s situation is unique, and it’s not difficult to imagine someone needing refills of this cream more or less often than every quarter. And though you do have the option to request an early refill or pause your subscription as needed, it would be nice to see the company add some subscription customization options in the future to make the process more convenient from the outset for customers with different needs. When purchasing from Wisp, your telehealth visit for prescriptions — like OMG! Cream — is included with the medication cost. And if you have an HSA/FSA account, you can either use a card at checkout or download the necessary documents for reimbursement. A 2021 study gave 48 healthy, menstruating women either 250mg of fenugreek extract twice a day or a placebo.
The research on tadalafil for women is pretty sparse, but the results that exist are promising. As noted in a 2017 review on phosphodiesterase type 5 (PDE5) inhibitors for FSD in older women,70 research has mainly focused on tadalafil for women with FSD due to antidepressants or diabetes.71 72 Both studies (using 5-20mg tadalafil) led to positive outcomes — all patients experienced improvement — but were limited by small sample sizes and lack of placebo control. As researchers continue to investigate the effects of PDE5 inhibitors in women, we’ll update this guide accordingly. Since L-citrulline gets converted in the body to L-arginine and nitric oxide, supplementing with this amino acid may lead to increased nitric oxide production.10 There really isn’t any research on oral L-citrulline supplementation alone for female sexual dysfunction or libido support, but some research on men found that 1,500mg could help treat mild to moderate erectile dysfunction.20 However, that’s nearly eight times the amount in Libido Lift Rx. But, to be fair, the L-citrulline in this prescription appears to play more of a supporting role than a main one.