It’s important to know whether the combination of these drugs is safe, as well as what its side effects might be. In this blog post, we will examine erectile dysfunction, premature ejaculation, and each drug individually. We will also look at the evidence surrounding the safety of taking Cialis with Dapoxetine, and provide clarity for patients who are considering taking these medications. The active ingredient in Priligy is dapoxetine, which is a drug used in the treatment of premature ejaculation.
Priligy works by delaying the reuptake of serotonin, a chemical in the brain that helps regulate mood.
Just be sure to always read the Patient Information Leaflet before taking any medication. Cialis (tadalafil) is a PDE5 inhibitor used to treat erectile dysfunction by increasing blood flow to the penis. Priligy (dapoxetine) is used to treat premature ejaculation by delaying the reuptake of serotonin. Taking Cialis and Dapoxetine together is not recommended. Combining these medications can cause side effects including low palpitation, headaches, and flushing. When serotonin is released, it travels through the brain and attaches to receptors on cells called neurons. Once the serotonin has attached to these receptors, it is pulled back into the neuron by proteins called transporters. Priligy blocks these transporters, which allows serotonin to stay attached to the receptors for a longer period of time.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Viagra Generic | 200mg | 270 + 10 Pills | 379.76€ 361.68€ | |
| Viagra Professional | 100mg | 120 + 4 Pills | 262.83€ 250.31€ | |
| Viagra Super Active | 100mg | 270 + 30 Pills | 390.61€ 372.01€ | |
| Viagra Generic | 50mg | 120 + 6 Pills | 129.64€ 123.47€ | |
| Viagra Generic | 150mg | 180 + 10 Pills | 236.46€ 225.20€ | |
| Viagra Oral Jelly | 100mg | 90 + 8 Sachets | 258.02€ 245.73€ | |
| Viagra Original | 100mg | 48 + 4 Pills | 207.15€ 197.29€ | |
| Viagra Soft Tabs | 100mg | 120 + 8 Pills | 232.21€ 221.15€ | |
| Viagra Generic | 50mg | 180 + 8 Pills | 158.82€ 151.26€ | |
| Viagra Super Active | 100mg | 180 + 20 Pills | 280.97€ 267.59€ | |
| Viagra Soft Tabs | 100mg | 10 Pills | 36.93€ 35.17€ | |
| Viagra Generic | 50mg | 30 + 4 Pills | 54.26€ 51.68€ | |
| Viagra Generic | 50mg | 10 Pills | 26.87€ 25.59€ | |
| Viagra Oral Jelly | 100mg | 63 + 7 Sachets | 190.54€ 181.47€ | |
| Viagra Professional | 100mg | 20 Pills | 71.14€ 67.75€ | |
| Viagra Super Active | 100mg | 60 + 8 Pills | 116.84€ 111.28€ |
This helps improve mood and reduce symptoms of depression.
Priligy is only licensed for use by men aged between 18 and 64 years. The effectiveness and safety of Priligy has not been established in patients aged 65 years and over. Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency, or glucose-galactose malabsorption should not take dapoxetine (Priligy). Most men benefit from dapoxetine (Priligy), but psychological therapies and direct physical treatments can be used at the same time and may increase the benefit. Priligy was first launched in the UK in 2013 and remained under patent until October 2025, so only the drug company Menarini could produce and sell the medicine.
When the patent expired, lower cost generic/unbranded versions became available and Menarini decided to no longer market Priligy. Dapoxetine is available on prescription in some NHS health authority areas, usually after specialist referral and advice - please check with your local GP surgery. NHS doctors will also usually be able to write private prescriptions for dapoxetine (charges will apply). Authored 28 July 2020 by Dr A. Reviewed by Dr C.
Pugh, Dr B. Babor Last reviewed 19 June 2023 Last updated 3 December 2025 Editorial policy Tadalafil side effects: how common are they? Like most medications, tadalafil can cause side effects. The most common are usually mild and will go away if you stop taking the tablets. Imagine the dilemma: ejaculate too soon, or risk losing your erection. Priligy is considered effective in treating premature ejaculation, which is caused by an overabundance of serotonin in the brain. By blocking the reuptake of serotonin, Priligy helps keep serotonin at high levels, which delays ejaculation and prolongs the time to orgasm [5][6]. The active ingredient in Viagra is sildenafil citrate, which belongs to a group of drugs called phosphodiesterase type 5 inhibitors. These drugs are designed to treat erectile dysfunction by relaxing the blood vessels in the penis, which allows for increased blood flow and an erection. Viagra works by inhibiting the enzyme phosphodiesterase type 5, which is responsible for degrading cyclic GMP (cGMP), a molecule that is important in the process of erection. When cGMP levels are increased, the muscles surrounding the blood vessels in the penis relax, allowing more blood to flow in and resulting in an erection [7]. Other medications similar to Viagra include sildenafil citrate (a non-branded alternative) and Viagra Connect (an over the counter alternative).
All these ED treatments contain the same active ingredient and function in the same way. Cialis contains tadalafil, another PDE5 inhibitor like sildenafil.
It works in a similar way – by increasing blood flow to the penis to help achieve and maintain erections – but is known for its longer duration of action No, it is not safe to take Cialis with Dapoxetine. It is also not safe to take Priligy and Viagra together.
If you experience any of these symptoms while taking both, stop taking them and contact your doctor immediately. Always speak to your GP before combining viagra red any medications for sexual dysfunction. If you have both erectile dysfunction and premature ejaculation, your doctor can advise on the safest and most appropriate treatment plan for your individual needs. Although both Cialis (Tadalafil) and Dapoxetine (Priligy) are effective treatments for male sexual dysfunction, there is a lot of confusion surrounding their safety when taken together. Some patients worry that taking the two medications will lead to an overdose or other adverse effects. As found in a study, taking them together can cause side effects, including low palpitation, headaches, and flushing (8). The study included 74 men with lifelong or acquired erectile dysfunction and premature ejaculation.
At the end of 4 weeks, 10 patients reported adverse side effects, as mentioned above. If you experience any of these side effects, stop taking both drugs and call your doctor right away. If you are taking a combination of these medications and feel dizzy, stop driving or doing tasks that require coordination. If you need treatment for either condition, talk to your doctor about which option is right for you. Also let your GP know if you are taking any other medicine, to avoid mixing medications that might be unsuitable or dangerous. It is important to take this medication exactly as directed unless otherwise instructed by your physician.
There is no interaction between topical anaesthetics and ED treatments like Sildenafil or Tadalafil, so they’re safe to use together. Paroxetine can be combined with either ED treatment. In fact, studies have shown that a combination of paroxetine and sildenafil can achieve better results for PE than paroxetine alone. Together, these drugs can cause low blood pressure, which could bring it to dangerous levels if combined, resulting in severe dizziness, feeling faint, or even collapse. Alcohol is often thought of as a solution to PE - but it can have the opposite effect.
Drinking large amounts can make it hard to get or keep an erection, or make it hard to have an orgasm at all. It also causes low blood pressure so should be avoided when taking Priligy, sildenafil, or tadalafil. Our clinicians can talk you through the options when you make a purchase. If you relax, you’re more likely to stay hard and you’re also less likely to come fast. Incorporating relaxation techniques, or discussing it with your partner are steps towards better sex.
Try methods like the stop-and-start technique for PE or practise losing and gaining an erection for ED. It’s better to realise they come and go. Squeezing the muscles you use to hold in urine or gas a few times a day, in quick and long bursts, can help you control erections and ejaculations. Do something about erectile dysfunction and premature ejaculation. It’s a confidence killer, but Delay Wipes, Delay Spray, and Paroxetine can be combined with sildenafil or tadalafil to attack the problem on all fronts, giving you the power to enjoy sex again. If you are considering purchasing these medications, it is best to do so from a trusted online pharmacy like e-Surgery. We offer safe and secure payment options, as well as discreet shipping, so that you can feel confident ordering these products online. Erectile Dysfunction (ED): Causes, Treatment, Symptoms, & More Healthline Efficacy of Dapoxetine in the Treatment of Premature Ejaculation NCBI Dapoxetine, a novel selective serotonin transport inhibitor for the treatment of premature ejaculation NCBI Viagra: Uses, How It works, How Long It Lasts, and More Healthline Efficacy and safety of dapoxetine/sildenafil combination tablets in the treatment of men with premature ejaculation and concomitant erectile dysfunction-DAP-SPEED Study NCBI The Efficacy and Safety of Dapoxetine/Sildenafil Combination Clinical Trials Premature Ejaculation: What you need to know Cornerstone Blog Efficacy and safety of dapoxetine/sildenafil combination IJIR Premature ejaculation (PE) and erectile dysfunction (ED) are the most prevalent sexual disorders in men. ED is commonly reported among patients with PE.
| Aspect | Priligy (Dapoxetine) | Viagra (Sildenafil) |
|---|---|---|
| Primary Effect | Serotonin reuptake inhibitor for premature ejaculation | PDE5 inhibitor for erectile dysfunction |
| Target Receptor | Serotonin transporter (SERT) | PDE5 enzyme |
| Main Purpose | Delay ejaculation | Improve blood flow for erection |
| Typical Use | Short-term, as needed | As-needed for ED |
Although recent guidelines recommend to treat ED first in men with both PE and ED, this recommendation is not based on evidence and there are limited data about the efficacy and safety of dapoxetine/sildenafil combination therapy for these patients.
| Side Effect | Priligy (Dapoxetine) | Viagra (Sildenafil) |
|---|---|---|
| Headache | Yes | Yes |
| Dizziness | Yes | Yes |
| Flushing | Rare | Common |
| Nasal Congestion | Rare | Rare |
| Gastrointestinal upset | Possible | Possible |
The aim of this study is to evaluate the clinical efficacy and safety of the dapoxetine/sildenafil combination (Dapoxil® 30/50 mg film-coated tablet) in the treatment of patients with PE and concomitant ED.
Premature ejaculation (PE) and erectile dysfunction (ED) can go hand in hand. And when it comes to sex, you don’t want to miss your shot. Let’s see which treatments can be combined to tackle the issue on both fronts. They’re the two most common male sexual problems and the root causes are often the same. High-stress levels, performance anxiety, and relationship problems are just a few examples that can cause both problems in the bedroom.
ED can even lead to the development of PE. You’re getting intimate, all the while focusing on staying hard. Arousal is high, but that leads to the point of no return faster than you’d like. Or, to avoid going soft, you try to cool off. It’s a tightrope walk where enjoyment takes a back seat.
It can lead to disappointment, frustration, or embarrassment. Not exactly feelings associated with enjoyable sex. There are many medications to treat both ED and PE. Sometimes they can even be used together - a double team to fight on both flanks. Delay Wipes and Delay Spray contain numbing agents such as lidocaine, which numbs your penis before sex, making you last longer.