This drug may be taken with or without food. In patients with anginal chest pain requiring nitroglycerin within 48 hours following intake of this drug, nitrates should be only be administered under close medical supervision with appropriate hemodynamic monitoring. This drug is indicated for treatment of erectile dysfunction, for signs and symptoms of benign prostate hyperplasia in male adult patients, and is also marketed as Adcirca (R) for the treatments of pulmonary arterial hypertension (PAH). Patients who experience cardiovascular symptoms upon initiation of sexual activity should refrain from further sexual activity and seek immediate medical attention. Patients taking this drug for erectile dysfunction should not take Adcirca (R) or other PDE5 inhibitors.
| Medication class | Effect on Tadalista 2.5 | Notes |
|---|---|---|
| Nitrates | Severe hypotension | Never combine |
| Alpha-blockers | Enhanced blood pressure lowering | Use with caution |
| CYP3A4 inhibitors | Increased Tadalafil levels | Dose adjustment may be required |
| CYP3A4 inducers | Reduced efficacy | Avoid or monitor |
| Antihypertensives | Possible additive effect | Monitor blood pressure |
Patients should seek emergency treatment if an erection, whether painful or not, lasts more than 4 hours. Patients should seek immediate medical attention in the event of a sudden loss of vision in one or both eyes while taking this drug. Patients should seek immediately medical attention in the event of sudden decrease or loss of hearing while taking this drug. Tadalafil (Erectile Dysfunction, Benign Prostatic Hyperplasia) monograph Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Tadalafil is a medicine that is commonly used for the following conditions. Erectile dysfunction, a condition where you have trouble getting or keeping an erection Pulmonary arterial hypertension, a condition where you have high blood pressure in the blood vessels that carry blood from your heart to your lungs Benign prostatic hyperplasia (BPH), a condition where the prostate gland has become enlarged Tadalafil may also be used for other conditions as determined by your healthcare provider. Tadalafil works by blocking the activity of an enzyme called phosphodiesterase 5 (PDE5).
Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings burning feeling in the chest or stomach feeling of constant movement of self or surroundings feeling of warmth, redness of the face, neck, arms and occasionally, upper chest redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid swelling or puffiness of the eyes or face Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Applies to the following strengths: 5 mg; 10 mg; 20 mg; 2.5 mg; 20 mg/5 mL Initial dose: 10 mg orally once a day, as needed, prior to sexual activity Maintenance dose: 5 to 20 mg orally once a day, as needed, prior to sexual activity based on individual efficacy and tolerability Comment: Consider that this drug has shown to improve erectile dysfunction up to 36 hours following dosing, when used as needed. Initial dose: 2.5 mg orally once a day at approximately the same time, without regard to timing of sexual activity Maintenance dose: 2.5 to 5 mg orally once a day based on individual efficacy and tolerability. Once daily use for ED and Benign Prostatic Hyperplasia (BPH): 5 mg orally once a day at approximately the same time, without regard to timing of sexual activity Comment: Dividing the 40 mg dose over the course of the day is not recommended. 5 mg orally once a day at approximately the same time 5 mg orally once a day at approximately the same time, for up to 26 weeks Comments: The incremental benefit of this drug decreases from 4 weeks until 26 weeks. The incremental benefit of this drug beyond 26 weeks sex medicine is unknown. This enzyme usually stops some types of muscles from relaxing, including the muscles lining some types of blood vessels. By blocking PDE5, the muscles will relax and blood flow increases. For erectile dysfunction, it increases blood flow to increase libido in women the penis when aroused. This makes it easier to get and keep an erection. For pulmonary arterial hypertension, tadalafil relaxes the blood vessels in the lungs. This lowers blood pressure and reduces strain on the heart.
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For benign prostatic hyperplasia, tadalafil relaxes the muscles of the bladder and prostate, making it easier to urinate and reducing symptoms.
Once daily use for ED and BPH: 5 mg orally once a day at approximately the same time, without regard to timing of sexual activity Use: Treatment of the signs and symptoms of benign prostatic hyperplasia (BPH) CrCl 30 to 50 mL/min: 5 mg orally once a day. The maximum dose is 10 mg not more than once in every 48 hours. CrCl less than 30 mL/min or on hemodialysis: The maximum dose is 5 mg orally once every 72 hours. CrCl 30 mL/min or greater: Data not available CrCl less than 30 mL/min or on hemodialysis: Not recommended. CrCl 30 to 50 mL/min: 2.5 orally once a day.
An increase to 5 mg may be considered based on individual response. CrCl less than 30 mL/min or on hemodialysis: Not recommended. CrCl 31 to 80 mL/min: 20 mg orally once a day. Increase to 40 mg orally once a day based on individual tolerability. CrCl less than 30 mL/min and on hemodialysis: Use should be avoided. Tadalafil should be stored at room temperature, between 68 F to 77 F (20 C to 25 C). It can be exposed to temperatures between 59 F to 86 F (15 C to 30 C) for shorter periods of time, such as when transporting it.
Mild to moderate hepatic dysfunction (Child-Pugh Class A and B): 10 mg orally once a day Severe hepatic dysfunction (Child-Pugh Class C): Not recommended. Mild to moderate hepatic dysfunction ed tablets (Child-Pugh Class A and B): Use with caution. Severe hepatic dysfunction (Child-Pugh Class C): Not recommended Mild to moderate hepatic dysfunction (Child-Pugh Class A and B): 20 mg orally once a day Severe hepatic dysfunction (Child-Pugh Class C): Use should be avoided. Erectile Dysfunction: 2.5 mg orally once a day Comment: Patients should be stable on alpha blocker therapy prior to initiating treatment with this drug. Concomitant administration with CYP450 3A4 inhibitors (ketoconazole, ritonavir): Use as needed for ED: No more than 10 mg orally every 72 hours Once a day dose for ED: No more than 2.5 mg orally once a day No dose adjustment is required in patients 65 years or older without renal impairment or hepatic impairment.
Coadministration of Adcirca (R) in patients on ritonavir: Increase to 40 mg once a day based upon individual tolerability. Coadministration of ritonavir in patients on Adcirca (R): Avoid use of Adcirca (R) during the initiation of ritonavir. Resume Adcirca (R) at 20 mg orally once a day, after at least 1 week following the initiation of ritonavir. Increase to 40 mg orally once a day based upon individual tolerability. Safety and efficacy have not been established in patients younger than 18 years. The most common side effects of tadalafil are listed below.
Do not drink excessive amounts of alcohol (eg, 5 or more glasses of wine or 5 or more shots of whiskey) when taking tadalafil. When taken in excess, alcohol can increase your chances of getting a headache or dizziness, increase your heart rate, or lower your blood pressure. If you experience sudden loss of vision in one or both eyes, contact your doctor immediately. Check with your doctor right away if you have a sudden decrease in hearing or loss of hearing, which may be accompanied by dizziness and ringing in the ears. Do not take other medicines unless they have been discussed with your doctor.
This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: faintness or lightheadedness when getting up suddenly from a lying or sitting position pain or discomfort in the arms, jaw, back, or neck Painful or prolonged erection of the penis blistering, peeling, or loosening of the skin fast, irregular, pounding, or racing heartbeat or pulse inability to move the arms, legs, or facial muscles numbness or tingling of the face, hands, or feet red skin lesions, often with a purple center sores, ulcers, or white spots in the mouth or on the lips swelling of the feet or lower legs Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. The side effects may vary depending upon the condition being treated.
| Aspect | Data or Comments | Source/Note |
|---|---|---|
| Success rate in ED cases | ~75-80% reported improvement | Clinical studies |
| Onset of action | Usually within 30-60 minutes | User reports |
| Duration of effect | Up to 36 hours | Pharmacological data |
| User satisfaction | Generally high, over 70% satisfied | Surveys and reviews |
| Repeat prescriptions | Common among patients | Prescriber data |
Tell your healthcare provider if you have any of these side effects that bother you. Pain in your muscles, back, arms, or legs There may be other side effects of tadalafil that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at or by calling 866-234-2345.
While less common, the most serious side effects of tadalafil are described below, along with what to do if they happen.
Tadalafil may cause allergic reactions, which can be serious. Stop taking tadalafil and get help right away if you have any of the following symptoms of a serious allergic reaction. Swelling of the face, lips, mouth, tongue, or throat Itching, skin rash, or pale red bumps on the skin called hives Tadalafil may cause an unwanted erection that is persistent, painful, and that may occur without sexual arousal.
| Parameter | Details | Typical Value | Notes |
|---|---|---|---|
| Absorption | Rapid, within 30-60 minutes | ~30 minutes | After oral intake |
| Peak Plasma Level | max plasma concentration | 2 hours | Slight variation possible |
| Half-life | Duration of effectiveness | 17.5 hours | Extended duration |
| Metabolism | Liver enzyme CYP3A4 | - | Mainly CYP3A4 enzyme |
| Excretion | Primarily feces and urine | - | Feces > Urine |
Permanent damage to the penis may occur if priapism is not treated quickly. Stop taking tadalafil and get emergency help right away if you have any of the following symptoms of priapism.